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Natural products for menopause often focus
on supplying high concentrations of phyto-estrogens to help modulate hormone levels, but typically do not address the increased vascular sensitivity that contributes to severity of symptoms in menopausal women.
HEAT RELIEF provides a more balanced
approach by providing natural ingredients
that minimize fluctuating hormone levels
while strengthening capillary resistance,
thereby improving the overall quality of life.
HEAT RELIEF combines botanical extracts
and nutrients whose efficacy has been
scientifically documented and can safely be
used by women in their perimenopausal,
menopausal, or postmenopausal years. The
recent addition of Norway Spruce (Picea
abies) containing 7-hydroxymatairesinol
(HMRlignan™), a natural plant lignan
shown to help alleviate menopausal
symptoms, enhances the benefits of
black cohosh extract, sage, hesperidin
methylchalcone, and gamma-oryzanol also
provided by HEAT RELIEF.
Black Cohosh (Cimicifuga racemosa):
A Widely Used Natural Remedy
Black cohosh herb contains a number of
biologically active substances, primarily
triterpene glycosides, flavonoids, phenolic
acids, and tannins. Native Americans and
early settlers used black cohosh roots and
rhizomes for a variety of ailments including
malaria, rheumatism, kidney dysfunction,
pain during childbirth, and menstrual difficulties.
Today, black cohosh is approved by
the German Commission E as a treatment
for menstrual and menopausal complaints
and is perhaps the most widely used natural
remedy for menopausal symptoms.
Over 70% of menopausal women
report vasomotor symptoms such
as flushing and night sweats, and
40-60% experience some form
of sleep disturbance.
Studiesindicate black cohosh has no estrogenic activity. Recent research has found
components of black cohosh can bind to
serotonin and/or dopamine receptors
suggesting a means by which the herb may
exert neuromodulatory and thermoregulatory
effects.
One double-blind, placebo controlled,
multi-center trial reported in the
journal Obstetrics & Gynecology examined
the effects of 40 mg/day of standardized
black cohosh extract in 145 postmenopausal
women experiencing climacteric symptoms.
After 12 weeks, scores on the standardized,
10-point Menopause Rating Scale were
significantly reduced from baseline in
women taking black cohosh compared to
the placebo group. Subgroup analyses found
women in their early menopausal years and
those suffering from hot flashes were the
most responsive to black cohosh treatment.
In another prospective trial, 48 menopausal
women were administered 80 mg/day of
black cohosh extract standardized to 2.5%
triterpene glycosides. After 12 weeks of treatment, mean symptom scores on the
Kupperman Menopausal Index decreased
significantly from 24.6 (indicative of
moderate symptoms) to 12.8 (indicative of
very mild symptoms). During a subsequent
12-week washout period, Kupperman
scores reverted back to near-baseline
levels. Importantly, this study evaluated
the impact of black cohosh on breast
tissue and found no significant changes
in nipple aspirate fluid cytology or
estrogenic markers over the 24-week
intervention and follow-up periods.
A double-blind, placebo-controlled trial
designed to compare the effect of
standardized black cohosh extract and
conjugated estrogens on postmenopausal
bone metabolism found both treatments
significantly improved serum markers of
bone turnover. Researchers noted black
cohosh elevated levels of bone-specific
alkaline phosphatase, an indicator of
increased osteoblastic bone formation,
while estrogen therapy tended to reduce
markers associated with osteoclastic bone
degradation.
Finally, in a prospective, parallel-controlled trial, 64 symptomatic postmenopausal women were administered either 40 mg/day of standardized black cohosh or a combination of transdermal estradiol and an oral progestin. After three months, both black cohosh and estrogen/progestin treatments were found to significantly reduce vasomotor symptoms, anxiety, and depression to an equivalent degree. Serum LDL levels significantly decreased in both treatment groups, while HDL was increased only in women taking black cohosh.
At least a dozen other clinical trials conducted in centers around the world
have reported benefits for black cohosh in
treating menopausal signs and symptoms.
Hesperidin Methylchalcone:
Helps Improve Vascular Strength
Hesperidin is a flavanone polyphenol and
one of the primary flavonoids in citrus fruits.
Hesperidin is a glycoside consisting of the
aglycone hesperetin and the disaccharide
sugar rutinose. Studies dating back to the
1930s report benefits of hesperidin in
improving vascular strength and resistance.
Gamma-Oryzanol:
Helps Relieve Menopausal Symptoms
Gamma-oryzanol is a mixture of unsaponifiable components from rice bran oil.
In humans, supplementation with 300 mg/day of gamma-oryzanol for periods ranging from 4-16 weeks has been shown to significantly reduce levels of total cholesterol, LDL cholesterol, triglycerides, apolipoprotein B, and serum lipid peroxides, while significantly increasing levels of HDL. Studies
conducted in Japan have also found
gamma-oryzanol to be an effective means
of ameliorating menopausal symptoms.
Sage (Salvia officinalis):
Herbal Support Against Hot Flashes
Sage is a spice and medicinal herb that has
been widely used throughout recorded
history for a variety of health complaints.
According to botanical experts, sage
possesses antioxidant, antimicrobial, and
antispasmodic properties along with a
capacity to relieve excessive perspiration.
Studies also indicate sage has anticholinesterase activity that can effectively
enhance mood, memory and cognitive
performance
After two months of treatment with sage, mean numbers of mild, moderate, severe, and very severe hot flashes were reduced by 46%, 62%, 79%, and 100%, respectively.
Lignans:
Modulate Estrogen Activity
Lignans are a type of phytoestrogen, chemically similar to isoflavones and naturally found in plants such as flaxseed, whole grains, and certain trees such as the Norway spruce.
Upon ingestion, most plant lignans are
chemically modified by intestinal bacteria
to the human lignans, enterolactone and
enterodiol. These enterolignans are absorbed and can modulate estrogen activity by interacting with estrogen receptors (ERs).
Like most phytoestrogens, lignans are believed to exert a biphasic effect, antagonizing ERs in the presence of high estrogen and acting as weak ER agonists when estrogen levels are low. In this way lignans have a normalizing effect on estrogen imbalances in the body.
A study examining the diets of 394 postmenopausal women found a significant association between cognitive performance and higher lignan intake.
HEAT RELIEF suggested use: 1 capsule twice daily.
60 veg. capsules; Suggested use is 1 capsule 2x daily with food
on supplying high concentrations of phyto-estrogens to help modulate hormone levels, but typically do not address the increased vascular sensitivity that contributes to severity of symptoms in menopausal women.
HEAT RELIEF provides a more balanced
approach by providing natural ingredients
that minimize fluctuating hormone levels
while strengthening capillary resistance,
thereby improving the overall quality of life.
HEAT RELIEF combines botanical extracts
and nutrients whose efficacy has been
scientifically documented and can safely be
used by women in their perimenopausal,
menopausal, or postmenopausal years. The
recent addition of Norway Spruce (Picea
abies) containing 7-hydroxymatairesinol
(HMRlignan™), a natural plant lignan
shown to help alleviate menopausal
symptoms, enhances the benefits of
black cohosh extract, sage, hesperidin
methylchalcone, and gamma-oryzanol also
provided by HEAT RELIEF.
Black Cohosh (Cimicifuga racemosa):
A Widely Used Natural Remedy
Black cohosh herb contains a number of
biologically active substances, primarily
triterpene glycosides, flavonoids, phenolic
acids, and tannins. Native Americans and
early settlers used black cohosh roots and
rhizomes for a variety of ailments including
malaria, rheumatism, kidney dysfunction,
pain during childbirth, and menstrual difficulties.
Today, black cohosh is approved by
the German Commission E as a treatment
for menstrual and menopausal complaints
and is perhaps the most widely used natural
remedy for menopausal symptoms.
Over 70% of menopausal women
report vasomotor symptoms such
as flushing and night sweats, and
40-60% experience some form
of sleep disturbance.
Studiesindicate black cohosh has no estrogenic activity. Recent research has found
components of black cohosh can bind to
serotonin and/or dopamine receptors
suggesting a means by which the herb may
exert neuromodulatory and thermoregulatory
effects.
One double-blind, placebo controlled,
multi-center trial reported in the
journal Obstetrics & Gynecology examined
the effects of 40 mg/day of standardized
black cohosh extract in 145 postmenopausal
women experiencing climacteric symptoms.
After 12 weeks, scores on the standardized,
10-point Menopause Rating Scale were
significantly reduced from baseline in
women taking black cohosh compared to
the placebo group. Subgroup analyses found
women in their early menopausal years and
those suffering from hot flashes were the
most responsive to black cohosh treatment.
In another prospective trial, 48 menopausal
women were administered 80 mg/day of
black cohosh extract standardized to 2.5%
triterpene glycosides. After 12 weeks of treatment, mean symptom scores on the
Kupperman Menopausal Index decreased
significantly from 24.6 (indicative of
moderate symptoms) to 12.8 (indicative of
very mild symptoms). During a subsequent
12-week washout period, Kupperman
scores reverted back to near-baseline
levels. Importantly, this study evaluated
the impact of black cohosh on breast
tissue and found no significant changes
in nipple aspirate fluid cytology or
estrogenic markers over the 24-week
intervention and follow-up periods.
A double-blind, placebo-controlled trial
designed to compare the effect of
standardized black cohosh extract and
conjugated estrogens on postmenopausal
bone metabolism found both treatments
significantly improved serum markers of
bone turnover. Researchers noted black
cohosh elevated levels of bone-specific
alkaline phosphatase, an indicator of
increased osteoblastic bone formation,
while estrogen therapy tended to reduce
markers associated with osteoclastic bone
degradation.
Finally, in a prospective, parallel-controlled trial, 64 symptomatic postmenopausal women were administered either 40 mg/day of standardized black cohosh or a combination of transdermal estradiol and an oral progestin. After three months, both black cohosh and estrogen/progestin treatments were found to significantly reduce vasomotor symptoms, anxiety, and depression to an equivalent degree. Serum LDL levels significantly decreased in both treatment groups, while HDL was increased only in women taking black cohosh.
At least a dozen other clinical trials conducted in centers around the world
have reported benefits for black cohosh in
treating menopausal signs and symptoms.
Hesperidin Methylchalcone:
Helps Improve Vascular Strength
Hesperidin is a flavanone polyphenol and
one of the primary flavonoids in citrus fruits.
Hesperidin is a glycoside consisting of the
aglycone hesperetin and the disaccharide
sugar rutinose. Studies dating back to the
1930s report benefits of hesperidin in
improving vascular strength and resistance.
Gamma-Oryzanol:
Helps Relieve Menopausal Symptoms
Gamma-oryzanol is a mixture of unsaponifiable components from rice bran oil.
In humans, supplementation with 300 mg/day of gamma-oryzanol for periods ranging from 4-16 weeks has been shown to significantly reduce levels of total cholesterol, LDL cholesterol, triglycerides, apolipoprotein B, and serum lipid peroxides, while significantly increasing levels of HDL. Studies
conducted in Japan have also found
gamma-oryzanol to be an effective means
of ameliorating menopausal symptoms.
Sage (Salvia officinalis):
Herbal Support Against Hot Flashes
Sage is a spice and medicinal herb that has
been widely used throughout recorded
history for a variety of health complaints.
According to botanical experts, sage
possesses antioxidant, antimicrobial, and
antispasmodic properties along with a
capacity to relieve excessive perspiration.
Studies also indicate sage has anticholinesterase activity that can effectively
enhance mood, memory and cognitive
performance
After two months of treatment with sage, mean numbers of mild, moderate, severe, and very severe hot flashes were reduced by 46%, 62%, 79%, and 100%, respectively.
Lignans:
Modulate Estrogen Activity
Lignans are a type of phytoestrogen, chemically similar to isoflavones and naturally found in plants such as flaxseed, whole grains, and certain trees such as the Norway spruce.
Upon ingestion, most plant lignans are
chemically modified by intestinal bacteria
to the human lignans, enterolactone and
enterodiol. These enterolignans are absorbed and can modulate estrogen activity by interacting with estrogen receptors (ERs).
Like most phytoestrogens, lignans are believed to exert a biphasic effect, antagonizing ERs in the presence of high estrogen and acting as weak ER agonists when estrogen levels are low. In this way lignans have a normalizing effect on estrogen imbalances in the body.
A study examining the diets of 394 postmenopausal women found a significant association between cognitive performance and higher lignan intake.
HEAT RELIEF suggested use: 1 capsule twice daily.
60 veg. capsules; Suggested use is 1 capsule 2x daily with food
